Cosmetics

Cosmetic – Aging and photoaging Sciences

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DNA Repair mechanisms ensure the integrity of the genome. They can be affected by aging, Reactive Oxygen Species, sun exposure, environmental pollutants affecting skin cells.
Defective DNA Repair systems result in premature aging, senescence and cell death.

The era of personalized cosmetics has come. Better knowledge of processes potentially harming our cells can be harnessed to develop effective tailored protection strategies.

LXRepair assays can be used to determine the DNA Repair capacities of primary skin cell (fibroblasts, keratinocytes), 3D models, stem cells, skin biopsies.
The DNA Repair Enzyme Signature precisely characterize individuals' protection levels against UV radiation, oxidative stress, lipid peroxidation, atmospheric pollutants.

The properties of potential DNA Repair modulators such as nutrition and life-style factors can be characterized

LXRepair helps cosmetics companies and academic researchers to understand how DNA damaging agents act, by establishing relevant models and developing effective and safe ingredients or skin protection strategies.

We would be happy to discuss your projects and propose customized assay services.

Toxicology

Environmental and Industrial Toxicology

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Biomarkers of exposure to carcinogens

DNA Repair mechanisms protect the genome from the carcinogenic effects of genotoxic attacks. Exposure to chemicals, ultra­violet radiation, ionizing radiation in the environment or following industrial/occupational accidents represents a risk for civilian populations and workers.
LXRepair aims to identify specific biomarkers of carcinogen exposure to develop better protection for individuals and populations.
LXRepair kits can characterize early and late effects of exposure in a range of models.

Individual susceptibility to cancer risk

DNA Repair mechanisms and DNA Repair signaling pathways can be modulated by genetic factors, the individual's history of exposure to carcinogens, their age and life-style.
As a result, susceptibility to environmental and occupational carcinogenic risk is an individual matter.
LXRepair addresses individual susceptibility in potentially exposed populations by identifying atypical DNA Repair Enzymatic Profiles that reveal altered DNA Repair processes.

Compounds affecting DNA Repair

LXRepair's assay can be used to screen chemical substances for inhibition of DNA Repair, thus helping to prevent potential hazards.