The missing functional
for personalized medicine
DNA Damage Response and DNA Repair
DNA Repair Enzyme Signature analysis
When genomics fails or is not relevant
Our alternative to genomic profiling is functional DNA Repair testing.
For complex enzymatic systems, characterization of enzymatic activity reveals the true pathway functionality. This information is unavailable via mutation or DNA sequence analysis.
that will be ineffective or will
induce drastic side effects.
LXRepair wishes to help
these patients by offering
a new stratification strategy
to provide effective personnalized
treatment for each individual.
Identifying the best possible therapy
for a given patient
and reducing adverse events
contribute to reducing
Stratifying patients and characterizing drug effect
They help make the drug development process safer by elucidating and validating the drug's mechanism of action.
- carcinogen-induced tumors
- cancers treated by DNA-damaging therapies (radiotherapy, chemotherapy)
- tumors displaying defects in DNA Repair and in the DNA Damage Response
Several versions of the assays can be proposed depending on the study design and its objectives.
The assays can also be adapted to control the drug's expected mechanism of action in line with the company's drug development strategy (monotherapy, combination).